Tramadol Drug Information

What is Tramadol used for?

Tramadol is used to relieve moderate to moderately severe pain. It also may be used to treat pain caused by surgery and chronic conditions such as cancer or joint pain.

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How should Tramadol be taken?

Tramadol comes as a tablet to take by mouth. It usually is taken every 4-6 hours as needed. It may be taken with or without food. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take Tramadol exactly as directed.

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What precautions should be taken when using Tramadol?

Prior to taking Tramadol review the following precautions:

• Allergies -Tell your doctor if you have ever had any unusual or allergic reaction to Tramadol or codeine or other narcotic analgesics. Also tell your health care professional if you are allergic to any other substances, such as foods, preservatives, or dyes.
  
• Pregnancy - Although studies on birth defects have not been done in pregnant women, Tramadol has not been reported to cause birth defects. In animal studies, there were drug-related birth defects observed. Studies done in animals given very high (toxic) doses resulted in lower than normal birth weights and some deaths in the fetuses and birth defects in some of the newborns.
  
• Breast-feeding - Tramadol passes into breast milk and may cause unwanted effects in nursing babies. Mothers should stop taking Tramadol while breast-feeding during treatment. Be sure you have discussed the risks and benefits of the medicine with your doctor.
  
• Contraindications - Inform your doctor and pharmacist what prescription and nonprescription medications you are taking, especially other pain relievers; carbamazepine (Tegretol); MAO inhibitors [phenelzine (Nardil) or tranylcypromine (Parnate)]; medications for depression; quinidine; sleeping pills; tranquilizers; and vitamins (see below).
  
• Medical Conditions - inform your physician if you have or have ever had kidney or liver disease, a history of seizures, or a history of alcohol or drug abuse, Abdominal or stomach conditions (Tramadol may hide signs of these medical conditions), head injury, etc.. If you are having surgery, including dental surgery, tell your physician or dentist that you are taking Tramadol.
  
• Children -There is no specific information concerning the relationship of age to the effects of Tramadol in patients less than 16 years of age.
  
• Older adults - Studies in older adults show that Tramadol has an increased half life (stays in the body a little longer than it does in younger adults).

Remember, Tramadol may make you drowsy, do not drive a car or operate machinery while taking Tramadol. Alcohol may add to the drowsiness caused by Trmadol.

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Are there any drug interactions associated with the use of Tramadol?

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking Tramadol, inform your doctor of all prescription and nonprescription medications you may use, especially the following:

• Carbamazepine (e.g., Tegretol)—May decrease the effects of Tramadol by decreasing the amount of medicine in the body
  
• Central nervous system (CNS) anti-depressants (e.g., SSRI-types such as fluoxetine or fluvoxamine) using these medicines with Tramadol may increase the chance of serious side effects or increase the risk of convulsions (seizures)
  
• Monoamine oxidase (MAO) inhibitors (furazolidone [e.g., Furoxone], isocarboxazid [e.g., Marplan], phenelzine [e.g., Nardil], procarbazine [e.g., Matulane], selegiline [e.g., Eldepryl], tranylcypromine [e.g., Parnate])—The chance of convulsions (seizures) may be increased.
  
• Neuroleptics - Chlorpromazine, Triflupromazine, Mesoridazine, Thioridazine, Acetophenazine, Fluphenazine HCl, Perphenazine, Prochlorperazine, Trifluoroperazine, Chlorprothixene, Thiothixine, Haloperidol, Loxapine, Molindone, Clozapine, Risperidone, Olanzapine, Quetiapine.
  
• Additional medications - carbamazepine, narcotic pain relievers (e.g., codeine), drugs used to aid sleep, antidepressants psychiatric medicine (e.g., nefazodone), "triptan"-type drugs, anti-anxiety drugs (e.g., diazepam), sibutramine, Digoxin, Warfarin, Coumadin. Also, report use of certain antihistamines (e.g., diphenhydramine) which are also present in many cough-and-cold products. Do not start or stop any medicine without doctor or pharmacist approval.
  
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What if I miss a dose of Trmadol?

Take the missed Tramadol dose as soon as you remember it. However, if it is almost time for the next Tramadol dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose of Trmadol to make up for a missed one.

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How should Tramadol be stored?

To store this medicine:

Keep out of the reach of children.
Store away from heat and direct light.
Do not store Tramadol tablets in the bathroom, near the kitchen sink, or in other damp places. Heat or moisture may cause the medicine to break down.
Do not keep outdated medicine or medicine no longer needed. Be sure that any discarded medicine is out of the reach of children.

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Are there any side effects associated with the use of Tramadol?

Although side effects from Tramadol are not common, they can occur. Tell your doctor if any of these symptoms are severe or do not go away:

• dizziness
• headache
• drowsiness
• blurred vision
• upset stomach
• vomiting
• diarrhea

Tramadol Notes:

If you think that this medicine is not working as well after you have been taking it for a few weeks, do not increase the dose. Instead, check with your medical doctor or dentist.

IMPORTANT NOTE: The above Tramadol information is intended to supplement, not substitute for, the expertise and judgment of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that use of the drug is safe, appropriate, or effective for you.