| Home |
| About Us |
| Order |
| Refill |
| Celebrex Faq's |
| Info Articles |
| Contact Us |
|
|
|
Arthritis affects over 37 million Americans, or approximately one in seven people people. Interestingly, greater than 50 percent of these individuals are under the age of 65. Prior to Celebrex, these individuals depended on the traditional non-steroidal anti-inflammatory medications (NSAIDs) such as Voltaren, Naprosyn, Lodine, etc. NSAIDs are a group of medications commonly used to treat arthritis secondary to their analgesic, anti-inflammatory, and fever-reducing properties. The mechanism of action of NSAIDs is the inhibition of the enzyme cyclooxygenase, which catalyzes arachidonic acid to prostaglandins and leukotrienes. Inflammatory stimuli such as injury or disease---->membrane phospholipids release arachidonic acid---->cyclooxygenase catalyzes arachidonic acid to prostaglandins and leukotrienes---- > prostaglandins create an inflammatory responce while leukotrienes effect the body’s control of temperature. NSAIDs, thus, interfere with prostaglandin and leukotriene production by inhibiting cyclooxygenase.font> Today, advances in research have shown that there are actually two types of the cyclooxygenase enzymes. Cox-1 which is responsible for protecting the stomach and Cox-2 responsible for inflammation. Unfortunately, traditional NSAIDs target both of these enzyme. Subsequently, these medications are associated with a high incidence of gastro-intestinal side-effects including dyspepsia, bleeding, ulceration and perforation of the stomach, small or large intestine. Celebrex is the first NSAID to selectively inhibit primarily the Cox-2 enzyme, while sparing the Cox-1 enzyme which is responsible for protecting the delicate lining of the stomach. Individuals now have a treatment option, that will effectively relieve their arthritic inflammation and subsequent pain, with potentially fewer side effects. Physicians are enthusiastically writing some 350,000 prescriptions for Celebrex per week. In fact, sales for this medication have surpassed the records previously set by Viagra. Currently, Celebrex® is only available by prescription. Get your Celebrex® prescription with an online consultation If approved, Celebrex® will be shipped to your home or office within 48 hours. |