Prevention v50, n6 (June,1998):84 (2 pages).COPYRIGHT 1998 Rodale Press Inc. When Propecia hit pharmacy shelves this year, it brought to the balding population a
huge promise--and plenty of questions. Here are the facts about the first and only hair regrowth pill.
Does it work? Propecia (generic name finasteride)
shows great promise for men. In clinical trials of 1,879 balding men, more than 80% of those taking Propecia experienced no hair loss during the two year period--even better, 66% showed
hair regrowth. In some men, results were seen in three months, but it may take longer.
Unlike minoxidil (Rogaine), whose mechanism has never been understood,
Propecia's success makes sense, says Ivan Cohen, MD, assistant professor of dermatology at Yale University School of Medicine in New Haven, CT. Propecia works by blocking the conversion of
testosterone into DHT (dihydrotestosterone), a hormone that shrinks hair follicles--a key factor in male hair loss. By reducing DHT levels 60%, Propecia can stop hair loss and in many cases
trigger hair growth, explains Keith Kaufman, MD, of Merck Research Laboratories, Propecia's makers in Rahway, NJ.
Can women use it? Not if they're of childbearing
age, says Dr. Kaufman. Propecia can cause birth defects when taken during pregnancy. In fact, pregnant women are discouraged from handling broken pills because the drug may be absorbed
through the skin.
As for other women, the jury's still out. Propecia works by acting on hormones such as testosterone. Since women tend to have lower levels
of this, the results may be different.
For women whose hair loss is due to high testosterone or low estrogen after menopause, there's a chance Propecia may work, says
Dr. Cohen. A more definitive answer is on the way: Results of a study on post-menopausal women with thinning hair are expected later this year.
Are there side effects?
The only reported side effects are decreased libido and impotence, but they're extremely rare. Only 1.8% of the men taking
Propecia experienced decreased libido, while 1.3% of those taking the placebo did. Of the men taking Propecia, 1.3% experienced impotence, while 0.7% of those taking the placebo did. Better
news: When they stopped taking the drug, these side effects went away. And in roughly 60% of the men who continued taking it, side effects disappeared.
RELATED ARTICLE: OTHER OPTIONS FOR FEMALE HAIR LOSS
* ROGAINE. The topical over-the-counter treatment that has been successful for some women.
* ESTROGEN SUPPLEMENTS. "Sometimes women on hormone replacement therapy find that their hair loss slows down," explains Ivan Cohen, MD, of Yale University.
